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Characterisation of cellular effects of Burkholderia pseudomallei cycle inhibiting factor (Cif)

Cycle inhibiting factors (Cifs) are type III secretion system effectors produced by some Gram-negative pathogenic bacteria including Burkholderia pseudomallei. Through their deamidase activity, Cifs inhibit the activity of Cullin RING E3 ubiquitin ligases (CRL). CRL inhibition induces the accumulati...

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Detalles Bibliográficos
Autores principales: Ng, Mei Ying, Gan, Yunn-Hwen, Hagen, Thilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078346/
https://www.ncbi.nlm.nih.gov/pubmed/29848489
http://dx.doi.org/10.1242/bio.028225