Effects of CYP3A5 and UGT2B7 variants on steady-state carbamazepine concentrations in Chinese epileptic patients

Carbamazepine (CBZ) is a widely used antiepileptic drug with large interindividual variability in serum concentrations. Previous studies found that CYP3A5∗3 (rs776746), UGT2B7∗2 (802C>T), and UGT2B7∗3 (211G>T) variants could change the enzymes’ activity, which may influence drug concentrations...

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Detalles Bibliográficos
Autores principales: Lu, Qiong, Huang, Yuan-Tao, Shu, Yi, Xu, Ping, Xiang, Da-Xiong, Qu, Qiang, Qu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078657/
https://www.ncbi.nlm.nih.gov/pubmed/30045320
http://dx.doi.org/10.1097/MD.0000000000011662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078657/
https://www.ncbi.nlm.nih.gov/pubmed/30045320
http://dx.doi.org/10.1097/MD.0000000000011662

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