Reversal of IDO-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme

Elevated tryptophan (Trp) catabolism in the tumor microenvironment (TME) can mediate immune suppression by upregulation of IFNg-inducible indoleamine 2,3-dioxygenase (IDO1) and/or ectopic expression of the predominantly liver-restricted enzyme tryptophan 2,3-dioxygenase (TDO)(1–5). Whether these eff...

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Detalles Bibliográficos
Autores principales: Triplett, Todd A., Garrison, Kendra C., Marshall, Nicholas, Donkor, Moses, Blazeck, John, Lamb, Candice, Qerqez, Ahlam, Dekker, Joseph D., Tano, Yuri, Wei-Cheng-Lu, Karamitros, Christos S., Ford, Kyle, Tan, Bing, Zhang, Michelle, McGovern, Karen, Coma, Silvia, Kumada, Yoichi, Yamany, Mena Sameh, Sentandreu, Enrique, Fromm, George, Tiziani, Stefano, Schreiber, Taylor H., Manfredi, Mark, Ehrlich, Lauren I. R., Stone, Everett, Georgiou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078800/
https://www.ncbi.nlm.nih.gov/pubmed/30010674
http://dx.doi.org/10.1038/nbt.4180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078800/
https://www.ncbi.nlm.nih.gov/pubmed/30010674
http://dx.doi.org/10.1038/nbt.4180

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