Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate

Type IIA topoisomerases (Top2s) manipulate the handedness of DNA crossovers by introducing a transient and protein-linked double-strand break in one DNA duplex, termed the DNA-gate, whose opening allows another DNA segment to be transported through to change the DNA topology. Despite the central imp...

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Detalles Bibliográficos
Autores principales: Chen, Shin-Fu, Huang, Nan-Lan, Lin, Jung-Hsin, Wu, Chyuan-Chuan, Wang, Ying-Ren, Yu, Yu-Jen, Gilson, Michael K., Chan, Nei-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078968/
https://www.ncbi.nlm.nih.gov/pubmed/30082834
http://dx.doi.org/10.1038/s41467-018-05406-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078968/
https://www.ncbi.nlm.nih.gov/pubmed/30082834
http://dx.doi.org/10.1038/s41467-018-05406-y

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