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Importance of secondary screening with clinical isolates for anti-leishmania drug discovery

The growing drug resistance (DR) raises major concerns for the control of visceral leishmaniasis (VL), a neglected disease lethal in 95 percent of the cases if left untreated. Resistance has rendered antimonials (SSG) obsolete in the Indian Sub-Continent (ISC) and the first miltefosine-resistant Lei...

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Detalles Bibliográficos
Autores principales: Hefnawy, Aya, Cantizani, Juan, Peña, Imanol, Manzano, Pilar, Rijal, Suman, Dujardin, Jean-Claude, De Muylder, Geraldine, Martin, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078976/
https://www.ncbi.nlm.nih.gov/pubmed/30082744
http://dx.doi.org/10.1038/s41598-018-30040-5