A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia

The adaptive cellular response to low oxygen tensions is mediated by the hypoxia‐inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF‐α and HIF‐β subunits. Prolonged HIF expression is a key contributor to cellular transformation, tumorigenesis and metastasis. As...

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Detalles Bibliográficos
Autores principales: Foxler, Daniel E, Bridge, Katherine S, Foster, John G, Grevitt, Paul, Curry, Sean, Shah, Kunal M, Davidson, Kathryn M, Nagano, Ai, Gadaleta, Emanuela, Rhys, Hefin I, Kennedy, Paul T, Hermida, Miguel A, Chang, Ting‐Yu, Shaw, Peter E, Reynolds, Louise E, McKay, Tristan R, Wang, Hsei‐Wei, Ribeiro, Paulo S, Plevin, Michael J, Lagos, Dimitris, Lemoine, Nicholas R, Rajan, Prabhakar, Graham, Trevor A, Chelala, Claude, Hodivala‐Dilke, Kairbaan M, Spendlove, Ian, Sharp, Tyson V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079541/
https://www.ncbi.nlm.nih.gov/pubmed/29930174
http://dx.doi.org/10.15252/emmm.201708304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079541/
https://www.ncbi.nlm.nih.gov/pubmed/29930174
http://dx.doi.org/10.15252/emmm.201708304

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