Sensory neuronal sensitisation occurs through HMGB-1–RAGE and TRPV1 in high-glucose conditions

Many potential causes for painful diabetic neuropathy have been proposed including actions of cytokines and growth factors. High mobility group protein B1 (HMGB1) is a RAGE (also known as AGER) agonist whose levels are increased in diabetes and that contributes to pain by modulating peripheral infla...

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Detalles Bibliográficos
Autores principales: Bestall, Samuel M., Hulse, Richard P., Blackley, Zoe, Swift, Matthew, Ved, Nikita, Paton, Kenneth, Beazley-Long, Nicholas, Bates, David O., Donaldson, Lucy F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080605/
https://www.ncbi.nlm.nih.gov/pubmed/29930087
http://dx.doi.org/10.1242/jcs.215939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080605/
https://www.ncbi.nlm.nih.gov/pubmed/29930087
http://dx.doi.org/10.1242/jcs.215939

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