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Sensory neuronal sensitisation occurs through HMGB-1–RAGE and TRPV1 in high-glucose conditions
Many potential causes for painful diabetic neuropathy have been proposed including actions of cytokines and growth factors. High mobility group protein B1 (HMGB1) is a RAGE (also known as AGER) agonist whose levels are increased in diabetes and that contributes to pain by modulating peripheral infla...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080605/ https://www.ncbi.nlm.nih.gov/pubmed/29930087 http://dx.doi.org/10.1242/jcs.215939 |