Cargando…

Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels generate rhythmic activity in the heart and brain. Isoform-specific functional differences reflect the specializations required for the various roles that they play. Despite a high sequence and structural similarity, HCN isoforms di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alvarez-Baron, Claudia P., Klenchin, Vadim A., Chanda, Baron
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080897/ https://www.ncbi.nlm.nih.gov/pubmed/29980633 http://dx.doi.org/10.1085/jgp.201812031

Ejemplares similares

Bipolar switching by HCN voltage sensor underlies hyperpolarization activation
por: Cowgill, John, et al.
Publicado: (2019)

Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 Channel
por: Burtscher, Verena, et al.
Publicado: (2023)

Interplay between VSD, pore, and membrane lipids in electromechanical coupling in HCN channels
por: Elbahnsi, Ahmad, et al.
Publicado: (2023)

Isoform dependent regulation of human HCN channels by cholesterol
por: Fürst, Oliver, et al.
Publicado: (2015)

Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating
por: Kasimova, Marina A, et al.
Publicado: (2019)

Structure and dynamics underlying elementary ligand binding events in human pacemaking channels
por: Goldschen-Ohm, Marcel P, et al.
Publicado: (2016)

Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel
por: Oelstrom, Kevin, et al.
Publicado: (2016)

HCN Channels and Heart Rate
por: Scicchitano, Pietro, et al.
Publicado: (2012)

Review: HCN Channels in the Heart
por: Depuydt, Anne-Sophie, et al.
Publicado: (2022)

Patch-clamp fluorometry–based channel counting to determine HCN channel conductance
por: Liu, Chang, et al.
Publicado: (2016)

Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: Ligand-independent relief of autoinhibition in HCN4
por: Liao, Zhandi, et al.
Publicado: (2012)

Identification of the Molecular Site of Ivabradine Binding to HCN4 Channels
por: Bucchi, Annalisa, et al.
Publicado: (2013)

HCN channels sense temperature and determine heart rate responses to heat
por: Wu, Yuejin, et al.
Publicado: (2023)

Activation gating in HCN2 channels
por: Hummert, Sabine, et al.
Publicado: (2018)

HCN Channels Modulators: The Need for Selectivity
por: Romanelli, Maria Novella, et al.
Publicado: (2016)

Regulation of HCN Channels by Protein Interactions
por: Peters, Colin H., et al.
Publicado: (2022)

A self-consistent approach for determining pairwise interactions that underlie channel activation
por: Chowdhury, Sandipan, et al.
Publicado: (2014)

Integrated Allosteric Model of Voltage Gating of Hcn Channels
por: Altomare, Claudia, et al.
Publicado: (2001)

Coupling Interactions between Voltage Sensors of the Sodium Channel as Revealed by Site-specific Measurements
por: Chanda, Baron, et al.
Publicado: (2004)

S4 Movement in a Mammalian HCN Channel
por: Vemana, Sriharsha, et al.
Publicado: (2004)

HCN Channels—Modulators of Cardiac and Neuronal Excitability
por: Herrmann, Stefan, et al.
Publicado: (2015)

Dysfunctional HCN ion channels in neurological diseases
por: DiFrancesco, Jacopo C., et al.
Publicado: (2015)

Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain
por: Dini, Leonardo, et al.
Publicado: (2018)

Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics
por: Arcisio-Miranda, Manoel, et al.
Publicado: (2010)

Regulation of Axonal HCN1 Trafficking in Perforant Path Involves Expression of Specific TRIP8b Isoforms
por: Wilkars, Wiebke, et al.
Publicado: (2012)

Thermodynamics of electromechanical coupling in voltage-gated ion channels
por: Chowdhury, Sandipan, et al.
Publicado: (2012)

Salts of HCN‐Cyanide Aggregates: [CN(HCN)(2)](−) and [CN(HCN)(3)](−)
por: Bläsing, Kevin, et al.
Publicado: (2020)

Free-energy relationships in ion channels activated by voltage and ligand
por: Chowdhury, Sandipan, et al.
Publicado: (2013)

The contribution of voltage clamp fluorometry to the understanding of channel and transporter mechanisms
por: Cowgill, John, et al.
Publicado: (2019)

Cooperative Gating between Single HCN Pacemaker Channels
por: Dekker, John P., et al.
Publicado: (2006)

The Role of HCN Channels on Membrane Excitability in the Nervous System
por: Kase, Daisuke, et al.
Publicado: (2012)

HCN Channels: New Therapeutic Targets for Pain Treatment
por: Ramírez, David, et al.
Publicado: (2018)

A Possible Link Between HCN Channels and Depression
por: Kim, Chung Sub, et al.
Publicado: (2018)

Gabapentin Modulates HCN4 Channel Voltage-Dependence
por: Tae, Han-Shen, et al.
Publicado: (2017)

Gating mechanism of hyperpolarization-activated HCN pacemaker channels
por: Ramentol, Rosamary, et al.
Publicado: (2020)

Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region
por: Page, Dana A., et al.
Publicado: (2020)

Electromechanical coupling mechanism for activation and inactivation of an HCN channel
por: Dai, Gucan, et al.
Publicado: (2021)

Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state
por: Cowgill, John, et al.
Publicado: (2023)

Correction: Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state
por: Cowgill, John, et al.
Publicado: (2023)

Tracking Voltage-dependent Conformational Changes in Skeletal Muscle Sodium Channel during Activation
por: Chanda, Baron, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_0n2b02sm0ints4lbvn9g0prdsj