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The N terminus of α-ENaC mediates ENaC cleavage and activation by furin
Epithelial Na(+) channels comprise three homologous subunits (α, β, and γ) that are regulated by alternative splicing and proteolytic cleavage. Here, we determine the basis of the reduced Na(+) current (I(Na)) that results from expression of a previously identified, naturally occurring splice varian...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080898/ https://www.ncbi.nlm.nih.gov/pubmed/29980634 http://dx.doi.org/10.1085/jgp.201711860 |