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A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses
To what extent immune responses against the gut flora are compartmentalized within mucosal tissues in homeostatic conditions remains a much-debated issue. We describe here, based on an inducible AID fate-mapping mouse model, that systemic memory B cell subsets, including mainly IgM(+) B cells in spl...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080908/ https://www.ncbi.nlm.nih.gov/pubmed/29959173 http://dx.doi.org/10.1084/jem.20180977 |