Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma

Ewing sarcoma is a pediatric cancer driven by EWS-ETS transcription factor fusion oncoproteins in an otherwise stable genomic background. The majority of tumors express wild-type TP53, and thus, therapies targeting the p53 pathway would benefit most patients. To discover targets specific for TP53 wi...

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Detalles Bibliográficos
Autores principales: Stolte, Björn, Iniguez, Amanda Balboni, Dharia, Neekesh V., Robichaud, Amanda L., Conway, Amy Saur, Morgan, Ann M., Alexe, Gabriela, Schauer, Nathan J., Liu, Xiaoxi, Bird, Gregory H., Tsherniak, Aviad, Vazquez, Francisca, Buhrlage, Sara J., Walensky, Loren D., Stegmaier, Kimberly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080915/
https://www.ncbi.nlm.nih.gov/pubmed/30045945
http://dx.doi.org/10.1084/jem.20171066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080915/
https://www.ncbi.nlm.nih.gov/pubmed/30045945
http://dx.doi.org/10.1084/jem.20171066

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