GATOR1-dependent recruitment of FLCN–FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids

Folliculin (FLCN) is a tumor suppressor that coordinates cellular responses to changes in amino acid availability via regulation of the Rag guanosine triphosphatases. FLCN is recruited to lysosomes during amino acid starvation, where it interacts with RagA/B as a heterodimeric complex with FLCN-inte...

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Detalles Bibliográficos
Autores principales: Meng, Jin, Ferguson, Shawn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080935/
https://www.ncbi.nlm.nih.gov/pubmed/29848618
http://dx.doi.org/10.1083/jcb.201712177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080935/
https://www.ncbi.nlm.nih.gov/pubmed/29848618
http://dx.doi.org/10.1083/jcb.201712177

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