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KCNE1 tunes the sensitivity of K(V)7.1 to polyunsaturated fatty acids by moving turret residues close to the binding site
The voltage-gated potassium channel K(V)7.1 and the auxiliary subunit KCNE1 together form the cardiac I(Ks) channel, which is a proposed target for future anti-arrhythmic drugs. We previously showed that polyunsaturated fatty acids (PUFAs) activate K(V)7.1 via an electrostatic mechanism. The activat...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080945/ https://www.ncbi.nlm.nih.gov/pubmed/30014849 http://dx.doi.org/10.7554/eLife.37257 |