Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

Rapid generation of drug-resistant mutations in HIV-1 reverse transcriptase (RT), a prime target for anti-HIV therapy, poses a major impediment to effective anti-HIV treatment. Our previous efforts have led to the development of two novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) with...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Kang, Dongwei, Nguyen, Laura A, Smithline, Zachary B, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong, Steitz, Thomas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080946/
https://www.ncbi.nlm.nih.gov/pubmed/30044217
http://dx.doi.org/10.7554/eLife.36340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080946/
https://www.ncbi.nlm.nih.gov/pubmed/30044217
http://dx.doi.org/10.7554/eLife.36340

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