Cargando…

Positive/Negative Allosteric Modulation Switching in an Umami Taste Receptor (T1R1/T1R3) by a Natural Flavor Compound, Methional

Taste is a vital sensation for vertebrates, enabling the detection of nutritionally important substances or potential toxins. A heteromeric complex of two class C GPCRs, T1R1 and T1R3, was identified as the umami (savory) taste receptor. Amino acids and 5′-ribonucleotides are well known to be natura...

Descripción completa

Detalles Bibliográficos
Autores principales:	Toda, Yasuka, Nakagita, Tomoya, Hirokawa, Takatsugu, Yamashita, Yuki, Nakajima, Ayako, Narukawa, Masataka, Ishimaru, Yoshiro, Uchida, Riichiro, Misaka, Takumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081381/ https://www.ncbi.nlm.nih.gov/pubmed/30087430 http://dx.doi.org/10.1038/s41598-018-30315-x

Ejemplares similares

Two Distinct Determinants of Ligand Specificity in T1R1/T1R3 (the Umami Taste Receptor)
por: Toda, Yasuka, et al.
Publicado: (2013)

Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor
por: Nakagita, Tomoya, et al.
Publicado: (2019)

Modulation of Sweet Taste by Umami Compounds via Sweet Taste Receptor Subunit hT1R2
por: Shim, Jaewon, et al.
Publicado: (2015)

Mouse neutrophils express functional umami taste receptor T1R1/T1R3
por: Lee, NaHye, et al.
Publicado: (2014)

Allosteric modulation of the fish taste receptor type 1 (T1R) family by the extracellular chloride ion
por: Goda, Ryusei, et al.
Publicado: (2023)

Evaluation of eight kinds of flavor enhancer of umami taste by an electronic tongue
por: Wang, Kai, et al.
Publicado: (2021)

Novel Umami Peptides from Hypsizygus marmoreus and Interaction with Umami Receptor T1R1/T1R3
por: Dong, Xiaobo, et al.
Publicado: (2023)

Suppression of hTAS2R16 Signaling by Umami Substances
por: Rhyu, Mee-Ra, et al.
Publicado: (2020)

Umami the Fifth Basic Taste: History of Studies on Receptor Mechanisms and Role as a Food Flavor
por: Kurihara, Kenzo
Publicado: (2015)

Biophysical and functional characterization of the N-terminal domain of the cat T1R1 umami taste receptor expressed in Escherichia coli
por: Belloir, Christine, et al.
Publicado: (2017)

Umami as an ‘Alimentary’ Taste. A New Perspective on Taste Classification
por: Hartley, Isabella E, et al.
Publicado: (2019)

Kokumi Taste Active Peptides Modulate Salt and Umami Taste
por: Rhyu, Mee-Ra, et al.
Publicado: (2020)

The umami receptor T1R1–T1R3 heterodimer is rarely formed in chickens
por: Yoshida, Yuta, et al.
Publicado: (2021)

Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys
por: Tsutsui, Kei, et al.
Publicado: (2016)

Comparison between the timing of the occurrence of taste sensitivity changes and short-term memory decline due to aging in SAMP1 mice
por: Narukawa, Masataka, et al.
Publicado: (2021)

Impact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival
por: Carey, Ryan M., et al.
Publicado: (2022)

Clofibrate inhibits the umami-savory taste of glutamate
por: Kochem, Matthew, et al.
Publicado: (2017)

Dataset of verbal evaluation of umami taste in Europe
por: Iannilli, Emilia, et al.
Publicado: (2020)

Expression of the synaptic exocytosis‐regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction
por: Kurokawa, Azusa, et al.
Publicado: (2015)

Genomic and Genetic Evidence for the Loss of Umami Taste in Bats
por: Zhao, Huabin, et al.
Publicado: (2012)

Loss or major reduction of umami taste sensation in pinnipeds
por: Sato, Jun J., et al.
Publicado: (2012)

Umami and Other Taste Perceptions in Patients With Parkinson’s Disease
por: Jagota, Priya, et al.
Publicado: (2022)

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes
por: Taruno, Akiyuki, et al.
Publicado: (2013)

Recent progress in the use of diaziridine-based sweetener derivatives to elucidate the chemoreception mechanism of the sweet taste receptor
por: Hashimoto, Makoto, et al.
Publicado: (2021)

Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer’s Disease
por: Narukawa, Masataka, et al.
Publicado: (2020)

Identification of Umami Taste in Sous-Vide Beef by Chemical Analyses, Equivalent Umami Concentration, and Electronic Tongue System
por: Hwang, Young-Hwa, et al.
Publicado: (2020)

Development of an Umami Taste Sensitivity Test and Its Clinical Use
por: Satoh-Kuriwada, Shizuko, et al.
Publicado: (2014)

Molecular evolution of umami/sweet taste receptor genes in reptiles
por: Feng, Ping, et al.
Publicado: (2018)

Sweet and Umami Taste Perception Differs with Habitual Exercise in Males
por: Feeney, Emma L., et al.
Publicado: (2019)

Polymorphic variants in Sweet and Umami taste receptor genes and birthweight
por: Farinella, Riccardo, et al.
Publicado: (2021)

Evolutionary insights into umami, sweet, and bitter taste receptors in amphibians
por: Zhong, Huaming, et al.
Publicado: (2021)

Sodium–Taste Cells Require Skn-1a for Generation and Share Molecular Features with Sweet, Umami, and Bitter Taste Cells
por: Ohmoto, Makoto, et al.
Publicado: (2020)

Genetic and Molecular Basis of Individual Differences in Human Umami Taste Perception
por: Shigemura, Noriatsu, et al.
Publicado: (2009)

Amino acid sensing in hypothalamic tanycytes via umami taste receptors
por: Lazutkaite, Greta, et al.
Publicado: (2017)

Umami synergy as the scientific principle behind taste-pairing champagne and oysters
por: Schmidt, Charlotte Vinther, et al.
Publicado: (2020)

Molecular insights into human taste perception and umami tastants: A review
por: Diepeveen, Johan, et al.
Publicado: (2022)

Characterization of the β-d-Glucopyranoside Binding Site of the Human Bitter Taste Receptor hTAS2R16
por: Sakurai, Takanobu, et al.
Publicado: (2010)

Zebrafish and medaka T1R (taste receptor type 1) proteins mediate highly sensitive recognition of l‐proline
por: Goda, Ryusei, et al.
Publicado: (2023)

Amino acid residues of bitter taste receptor TAS2R16 that determine sensitivity in primates to β-glycosides
por: Imai, Hiroo, et al.
Publicado: (2016)

Sweet, Salty, and Umami Taste Sensitivity and the Hedonic Perception of Taste Sensations in Adolescent Females with Anorexia Nervosa
por: Hartman-Petrycka, Magdalena, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_08v9pb2ap05cgtrml6vl7j8voh