Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases

MAPK/ERK kinase (MEK) 1/2 are central signaling proteins that serve as specificity determinants of the MAPK/ERK cascade. More than twenty activating mutations have been reported for MEK1/2, and many of them are known to cause diseases such as cancers, arteriovenous malformation and RASopathies. Chan...

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Detalles Bibliográficos
Autores principales: Ordan, Merav, Pallara, Chiara, Maik-Rachline, Galia, Hanoch, Tamar, Gervasio, Francesco Luigi, Glaser, Fabian, Fernandez-Recio, Juan, Seger, Rony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081382/
https://www.ncbi.nlm.nih.gov/pubmed/30087384
http://dx.doi.org/10.1038/s41598-018-30202-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081382/
https://www.ncbi.nlm.nih.gov/pubmed/30087384
http://dx.doi.org/10.1038/s41598-018-30202-5

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