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Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases
MAPK/ERK kinase (MEK) 1/2 are central signaling proteins that serve as specificity determinants of the MAPK/ERK cascade. More than twenty activating mutations have been reported for MEK1/2, and many of them are known to cause diseases such as cancers, arteriovenous malformation and RASopathies. Chan...
Autores principales: | Ordan, Merav, Pallara, Chiara, Maik-Rachline, Galia, Hanoch, Tamar, Gervasio, Francesco Luigi, Glaser, Fabian, Fernandez-Recio, Juan, Seger, Rony |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081382/ https://www.ncbi.nlm.nih.gov/pubmed/30087384 http://dx.doi.org/10.1038/s41598-018-30202-5 |
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