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ATP activates bestrophin ion channels through direct interaction
Human Bestrophin1 (hBest1) is a Ca(2+)-activated Cl(−) channel in retinal pigment epithelium (RPE) essential for retina physiology, and its mutation results in retinal degenerative diseases that have no available treatments. Here, we discover that hBest1’s channel activity in human RPE is significan...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081419/ https://www.ncbi.nlm.nih.gov/pubmed/30087350 http://dx.doi.org/10.1038/s41467-018-05616-4 |