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ATP activates bestrophin ion channels through direct interaction

Human Bestrophin1 (hBest1) is a Ca(2+)-activated Cl(−) channel in retinal pigment epithelium (RPE) essential for retina physiology, and its mutation results in retinal degenerative diseases that have no available treatments. Here, we discover that hBest1’s channel activity in human RPE is significan...

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Detalles Bibliográficos
Autores principales:	Zhang, Yu, Kittredge, Alec, Ward, Nancy, Ji, Changyi, Chen, Shoudeng, Yang, Tingting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081419/ https://www.ncbi.nlm.nih.gov/pubmed/30087350 http://dx.doi.org/10.1038/s41467-018-05616-4

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