Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation

Little is known about miRNA decay. A target-directed miRNA degradation mechanism (TDMD) has been suggested, but further investigation on endogenous targets is necessary. Here, we identify hundreds of targets eligible for TDMD and show that an endogenous RNA (Serpine1) controls the degradation of two...

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Detalles Bibliográficos
Autores principales: Ghini, Francesco, Rubolino, Carmela, Climent, Montserrat, Simeone, Ines, Marzi, Matteo J., Nicassio, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081425/
https://www.ncbi.nlm.nih.gov/pubmed/30087332
http://dx.doi.org/10.1038/s41467-018-05182-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081425/
https://www.ncbi.nlm.nih.gov/pubmed/30087332
http://dx.doi.org/10.1038/s41467-018-05182-9

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