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Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation
Little is known about miRNA decay. A target-directed miRNA degradation mechanism (TDMD) has been suggested, but further investigation on endogenous targets is necessary. Here, we identify hundreds of targets eligible for TDMD and show that an endogenous RNA (Serpine1) controls the degradation of two...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081425/ https://www.ncbi.nlm.nih.gov/pubmed/30087332 http://dx.doi.org/10.1038/s41467-018-05182-9 |