Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma

An array of oncogenic histone point mutations have been identified across a number of different cancer studies. It has been suggested that some of these mutant histones can exert their effects by inhibiting epigenetic writers. Here, we report that the H3.3 G34R (glycine to arginine) substitution mut...

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Detalles Bibliográficos
Autores principales: Voon, Hsiao P. J., Udugama, Maheshi, Lin, Wendi, Hii, Linda, Law, Ruby H.P., Steer, David L., Das, Partha P., Mann, Jeffrey R., Wong, Lee H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081460/
https://www.ncbi.nlm.nih.gov/pubmed/30087349
http://dx.doi.org/10.1038/s41467-018-05607-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081460/
https://www.ncbi.nlm.nih.gov/pubmed/30087349
http://dx.doi.org/10.1038/s41467-018-05607-5

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