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Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress

Abnormal hippocampal neural plasticity has been implicated in behavioural abnormalities and complex neuropsychiatric conditions, including bipolar disorder (BD). However, the determinants of this neural alteration remain unknown. This work tests the hypothesis that the neurotransmitter serotonin (5-...

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Detalles Bibliográficos
Autores principales: Maddaloni, Giacomo, Migliarini, Sara, Napolitano, Francesco, Giorgi, Andrea, Nazzi, Serena, Biasci, Daniele, De Felice, Alessia, Gritti, Marta, Cavaccini, Anna, Galbusera, Alberto, Franceschi, Sara, Lessi, Francesca, Ferla, Marco La, Aretini, Paolo, Mazzanti, Chiara Maria, Tonini, Raffaella, Gozzi, Alessandro, Usiello, Alessandro, Pasqualetti, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081464/
https://www.ncbi.nlm.nih.gov/pubmed/30087403
http://dx.doi.org/10.1038/s41598-018-30291-2