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Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats

BACKGROUND: Src homology 2 containing protein tyrosine phosphatase (PTP) 2 (Shp2) is a typical tyrosine phosphatase interacting with receptor tyrosine kinase to regulate multiple signaling pathways in diverse pathological processes. Here, we will investigate the effect of Shp2 inhibition on pulmonar...

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Detalles Bibliográficos
Autores principales: Cheng, Yusheng, Yu, Min, Xu, Jian, He, Mengyu, Wang, Hong, Kong, Hui, Xie, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081862/
https://www.ncbi.nlm.nih.gov/pubmed/30086741
http://dx.doi.org/10.1186/s12890-018-0700-y