Statistical relationship between metabolic decomposition and chemical uptake predicts bioconcentration factor data for diverse chemical exposures

BACKGROUND: A challenge of in vitro to in vivo extrapolation (IVIVE) is to predict the physical state of organisms exposed to chemicals in the environment from in vitro exposure assay data. Although toxicokinetic modeling approaches promise to bridge in vitro screening data with in vivo effects, the...

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Detalles Bibliográficos
Autores principales: Rowland, Michael A., Wear, Hannah, Watanabe, Karen H., Gust, Kurt A., Mayo, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081876/
https://www.ncbi.nlm.nih.gov/pubmed/30086736
http://dx.doi.org/10.1186/s12918-018-0601-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081876/
https://www.ncbi.nlm.nih.gov/pubmed/30086736
http://dx.doi.org/10.1186/s12918-018-0601-y

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