CTCF maintains regulatory homeostasis of cancer pathways

BACKGROUND: CTCF binding to DNA helps partition the mammalian genome into discrete structural and regulatory domains. Complete removal of CTCF from mammalian cells causes catastrophic genome dysregulation, likely due to widespread collapse of 3D chromatin looping and alterations to inter- and intra-...

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Detalles Bibliográficos
Autores principales: Aitken, Sarah J., Ibarra-Soria, Ximena, Kentepozidou, Elissavet, Flicek, Paul, Feig, Christine, Marioni, John C., Odom, Duncan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081938/
https://www.ncbi.nlm.nih.gov/pubmed/30086769
http://dx.doi.org/10.1186/s13059-018-1484-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081938/
https://www.ncbi.nlm.nih.gov/pubmed/30086769
http://dx.doi.org/10.1186/s13059-018-1484-3

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