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Mechanisms of genetic instability caused by (CGG)(n) repeats in an experimental mammalian system
We describe a new experimental system to study genome instability caused by fragile X (CGG)(n) repeats in mammalian cells. It is based on a selectable cassette carrying the HyTK gene under the control of the FMR1 promoter with (CGG)(n) repeats in its 5′-UTR, which was integrated into the unique RL5...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082162/ https://www.ncbi.nlm.nih.gov/pubmed/30061600 http://dx.doi.org/10.1038/s41594-018-0094-9 |