Heterogeneity of circulating CD8 T-cells specific to islet, neo-antigen and virus in patients with type 1 diabetes mellitus

Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting in type 1 diabetes (T1D). However, the phenotype of these auto-reactive cytolytic CD8 T-cells has not yet been extensively described. We used high-dimensional mass cytometry to phenotype autoantigen-...

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Detalles Bibliográficos
Autores principales: Laban, Sandra, Suwandi, Jessica S., van Unen, Vincent, Pool, Jos, Wesselius, Joris, Höllt, Thomas, Pezzotti, Nicola, Vilanova, Anna, Lelieveldt, Boudewijn P. F., Roep, Bart O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082515/
https://www.ncbi.nlm.nih.gov/pubmed/30089176
http://dx.doi.org/10.1371/journal.pone.0200818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082515/
https://www.ncbi.nlm.nih.gov/pubmed/30089176
http://dx.doi.org/10.1371/journal.pone.0200818

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