Histidine catabolism is a major determinant of methotrexate sensitivity

The chemotherapeutic drug methotrexate inhibits the enzyme DHFR (dihydrofolate reductase)(1), which generates tetrahydrofolate (THF), an essential cofactor in nucleotide synthesis(2). Depletion of THF causes cell death by suppressing DNA and RNA production(3). While methotrexate is widely used as an...

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Detalles Bibliográficos
Autores principales: Kanarek, Naama, Keys, Heather R., Cantor, Jason R., Lewis, Caroline A., Chan, Sze Ham, Kunchok, Tenzin, Abu-Remaileh, Monther, Freinkman, Elizaveta, Schweitzer, Lawrence D., Sabatini, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082631/
https://www.ncbi.nlm.nih.gov/pubmed/29995852
http://dx.doi.org/10.1038/s41586-018-0316-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082631/
https://www.ncbi.nlm.nih.gov/pubmed/29995852
http://dx.doi.org/10.1038/s41586-018-0316-7

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