Cargando…

Histidine catabolism is a major determinant of methotrexate sensitivity

The chemotherapeutic drug methotrexate inhibits the enzyme DHFR (dihydrofolate reductase)(1), which generates tetrahydrofolate (THF), an essential cofactor in nucleotide synthesis(2). Depletion of THF causes cell death by suppressing DNA and RNA production(3). While methotrexate is widely used as an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kanarek, Naama, Keys, Heather R., Cantor, Jason R., Lewis, Caroline A., Chan, Sze Ham, Kunchok, Tenzin, Abu-Remaileh, Monther, Freinkman, Elizaveta, Schweitzer, Lawrence D., Sabatini, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082631/ https://www.ncbi.nlm.nih.gov/pubmed/29995852 http://dx.doi.org/10.1038/s41586-018-0316-7

Ejemplares similares

Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
por: Pedram, Kayvon, et al.
Publicado: (2022)

MFSD12 mediates the import of cysteine into melanosomes and lysosomes
por: Adelmann, Charles H., et al.
Publicado: (2020)

Dihydroxyacetone phosphate signals glucose availability to mTORC1
por: Orozco, Jose M., et al.
Publicado: (2020)

Fluorouracil Catabolism in the Combination Treatment of Cyclophosphamide, Methotrexate and Fluorouracil
por: De Bruijn, Ernst A., et al.
Publicado: (1992)

Folate catabolism in tumour-bearing rats and rats treated with methotrexate.
por: Saleh, A. M., et al.
Publicado: (1981)

MCART1/SLC25A51 is required for mitochondrial NAD transport
por: Kory, Nora, et al.
Publicado: (2020)

WWOX somatic ablation in skeletal muscles alters glucose metabolism
por: Abu-Remaileh, Muhannad, et al.
Publicado: (2019)

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
por: Sullivan, Mark R, et al.
Publicado: (2019)

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
por: Garcia-Bermudez, Javier, et al.
Publicado: (2019)

Ferroptosis regulation by the NGLY1/NFE2L1 pathway
por: Forcina, Giovanni C., et al.
Publicado: (2022)

ClC transporter activity modulates histidine catabolism in Lactobacillus reuteri by altering intracellular pH and membrane potential
por: Hall, Anne E., et al.
Publicado: (2019)

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
por: Yu, Zhou, et al.
Publicado: (2018)

Embryonic Stem Cell (ES)-Specific Enhancers Specify the Expression Potential of ES Genes in Cancer
por: Aran, Dvir, et al.
Publicado: (2016)

Dynamic interactions between Candida albicans and different streptococcal species in a multispecies oral biofilm
por: Lueyar, Tenzin Kunchok, et al.
Publicado: (2023)

A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate
por: Pacold, Michael E., et al.
Publicado: (2016)

Synovial membrane immunohistology in early-untreated rheumatoid arthritis reveals high expression of catabolic bone markers that is modulated by methotrexate
por: Revu, Shankar, et al.
Publicado: (2013)

Notes from the 2022 Folate, Vitamin B12, and One-Carbon Metabolism Conference
por: Maynard, Adam G., et al.
Publicado: (2023)

Correction: Maynard et al. Notes from the 2022 Folate, Vitamin B12, and One-Carbon Metabolism Conference. Metabolites 2023, 13, 486
por: Maynard, Adam G., et al.
Publicado: (2023)

Sequence variation in G-protein-coupled receptors: analysis of single nucleotide polymorphisms
por: Balasubramanian, Suganthi, et al.
Publicado: (2005)

Carboplatin binding to histidine
por: Tanley, Simon W. M., et al.
Publicado: (2014)

Golgi-IP, a tool for multimodal analysis of Golgi molecular content
por: Fasimoye, Rotimi, et al.
Publicado: (2023)

An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation
por: Scharenberg, Samantha G., et al.
Publicado: (2023)

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
por: Wolfson, Rachel L., et al.
Publicado: (2017)

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
por: Epsztejn-Litman, Silvina, et al.
Publicado: (2008)

Bacterial Catabolism of Dimethylsulfoniopropionate (DMSP)
por: Reisch, Chris R., et al.
Publicado: (2011)

Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin
por: Hintzen, Jordi C. J., et al.
Publicado: (2022)

First and second doses of Covishield vaccine provided high level of protection against SARS-CoV-2 infection in highly transmissible settings: results from a prospective cohort of participants residing in congregate facilities in India
por: Tsundue, Tenzin, et al.
Publicado: (2022)

Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis
por: Endo, Tsutomu, et al.
Publicado: (2017)

Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities
por: Franco, Jorge, et al.
Publicado: (2020)

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
por: Luengo, Alba, et al.
Publicado: (2019)

Hypercatabolism and Anti-catabolic Therapies in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome
por: Zhang, Jinlin, et al.
Publicado: (2022)

Gaining Confidence in the Elusive Histidine Phosphoproteome
por: Potel, Clement M., et al.
Publicado: (2019)

DEXAMETHASONE: CHONDROPROTECTIVE CORTICOSTEROID OR CATABOLIC KILLER?
por: Black, R., et al.
Publicado: (2019)

High Prevalence of Active and Latent Tuberculosis in Children and Adolescents in Tibetan Schools in India: The Zero TB Kids Initiative in Tibetan Refugee Children
por: Dorjee, Kunchok, et al.
Publicado: (2019)

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential
por: Knudsen, Erik S., et al.
Publicado: (2016)

2-Fluoro-l-histidine
por: Andra, Kiran K., et al.
Publicado: (2010)

Aberrant DNA Methylation in ES Cells
por: Ludwig, Guy, et al.
Publicado: (2014)

Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells
por: Hsu, Jake, et al.
Publicado: (2022)

Histidine Hydrogen-Deuterium Exchange Mass Spectrometry for Probing the Microenvironment of Histidine Residues in Dihydrofolate Reductase
por: Miyagi, Masaru, et al.
Publicado: (2011)

Histidine Residue 94 Is Involved in pH Sensing by Histidine Kinase ArsS of Helicobacter pylori
por: Müller, Stefanie, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_pleml1qt7n5n1e2gmpr8sg0dci