Cargando…

Kisspeptin/GPR54 signaling restricts antiviral innate immune response through regulating calcineurin phosphatase activity

G protein–coupled receptor 54 (GPR54), the key receptor for the neuropeptide hormone kisspeptin, plays essential roles in regulating puberty development and cancer metastasis. However, its role in the antiviral innate immune response is unknown. We report that virus-induced type I interferon (IFN-I)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Hongjun, Xiong, Qingqing, Wang, Ning, Chen, Ruoyu, Ren, Hua, Siwko, Stefan, Han, Honghui, Liu, Mingyao, Qian, Min, Du, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082648/ https://www.ncbi.nlm.nih.gov/pubmed/30101190 http://dx.doi.org/10.1126/sciadv.aas9784

Ejemplares similares

Kisspeptin Receptor GPR54 Promotes Adipocyte Differentiation and Fat Accumulation in Mice
por: Wang, Tongtong, et al.
Publicado: (2018)

Kisspeptin and GPR54 Receptor Expression in Endometrial Cancer Tissue
por: Gowkielewicz, Marek, et al.
Publicado: (2023)

Neuroendocrine Regulation of Stress‐Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway
por: Zhang, Su, et al.
Publicado: (2022)

Metabolite-Sensing G Protein Coupled Receptor TGR5 Protects Host From Viral Infection Through Amplifying Type I Interferon Responses
por: Xiong, Qingqing, et al.
Publicado: (2018)

Kisspeptin-13 inhibits bleomycin-induced pulmonary fibrosis through GPR54 in mice
por: Lei, Zelin, et al.
Publicado: (2019)

Development and Aging of the Kisspeptin–GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function?
por: Franceschini, Isabelle, et al.
Publicado: (2013)

Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system
por: Zhou, Zhiyang, et al.
Publicado: (2019)

Potent Vasoconstrictor Kisspeptin‐10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist
por: Sato, Kengo, et al.
Publicado: (2017)

Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma
por: Prentice, Leah M, et al.
Publicado: (2007)

Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation
por: Son, Hyo-Eun, et al.
Publicado: (2018)

In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation
por: Albers-Wolthers, C. H. J., et al.
Publicado: (2017)

Exposure to a Complex Cocktail of Environmental Endocrine-Disrupting Compounds Disturbs the Kisspeptin/GPR54 System in Ovine Hypothalamus and Pituitary Gland
por: Bellingham, Michelle, et al.
Publicado: (2009)

Kisspeptin-10 Induces β-Casein Synthesis via GPR54 and Its Downstream Signaling Pathways in Bovine Mammary Epithelial Cells
por: Sun, Jianhua, et al.
Publicado: (2017)

Combined effects of obesity and di-(2-ethylhexyl) phthalate on testosterone levels and kisspeptin/GPR54 expression in hypothalamus and testes of male mice
por: Zhai, Ling-Ling, et al.
Publicado: (2020)

Maternal cafeteria diet influences kisspeptin (Kiss1), kisspeptin receptor(Gpr54), and sirtuin (Sirt1) genes, hormonal and metabolic profiles, and reproductive functions in rat offspring in a sex-specific manner
por: Matuszewska, Julia, et al.
Publicado: (2023)

Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men
por: Jayasena, C.N., et al.
Publicado: (2015)

Kisspeptin/G protein-coupled receptor-54 system as an essential gatekeeper of pubertal development
por: Rhie, Young-Jun
Publicado: (2013)

Increasing LH Pulsatility in Women With Hypothalamic Amenorrhoea Using Intravenous Infusion of Kisspeptin-54
por: Jayasena, Channa N., et al.
Publicado: (2014)

Regulation of body length and bone mass by Gpr126/Adgrg6
por: Sun, Peng, et al.
Publicado: (2020)

Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin
por: Masaki, Takahiro, et al.
Publicado: (2022)

Calcineurin regulates innate antifungal immunity in neutrophils
por: Greenblatt, Matthew B., et al.
Publicado: (2010)

OR33-4 A Single Subcutaneous Injection Of The Kisspeptin Analogue, MVT-602, Induces A More Prolonged LH Surge Compared With Kisspeptin-54 In Healthy Women
por: Clarke, Sophie, et al.
Publicado: (2019)

Twice-Daily Subcutaneous Injection of Kisspeptin-54 Does Not Abolish Menstrual Cyclicity in Healthy Female Volunteers
por: Jayasena, C. N., et al.
Publicado: (2013)

Subcutaneous infusion of kisspeptin‐54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels
por: Narayanaswamy, Shakunthala, et al.
Publicado: (2015)

Novel DNA variation of GPR54 gene in familial central precocious puberty
por: Ghaemi, Nosrat, et al.
Publicado: (2019)

Kisspeptin/Kisspeptin Receptor System in the Ovary
por: Hu, Kai-Lun, et al.
Publicado: (2018)

GPR54-Dependent Stimulation of Luteinizing Hormone Secretion by Neurokinin B in Prepubertal Rats
por: Grachev, Pasha, et al.
Publicado: (2012)

Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane
por: Ulengin-Talkish, Idil, et al.
Publicado: (2021)

GPR54 (KISS1R) Transactivates EGFR to Promote Breast Cancer Cell Invasiveness
por: Zajac, Mateusz, et al.
Publicado: (2011)

The KiSS-1/GPR54 system: Essential roles in physiological homeostasis and cancer biology
por: Zhu, Nisha, et al.
Publicado: (2020)

Recombinant B2L and Kisspeptin-54 DNA Vaccine Induces Immunity Against Orf Virus and Inhibits Spermatogenesis In Rats
por: Wassie, Teketay, et al.
Publicado: (2019)

From phagocytosis to metaforosis: Calcineurin’s deadly role in innate processing of fungi
por: Armstrong-James, Darius, et al.
Publicado: (2018)

Specific immunosuppressive role of nanodrugs targeting calcineurin in innate myeloid cells
por: Colombo, Miriam, et al.
Publicado: (2022)

GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation
por: Liu, Qianjin, et al.
Publicado: (2021)

Calcineurin phosphatase activity regulates Varicella-Zoster Virus induced cell-cell fusion
por: Zhou, Momei, et al.
Publicado: (2020)

Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation
por: Hu, Kai-Lun, et al.
Publicado: (2019)

The effect of high-fat diet and exercise on KISS-1/GPR54 expression in testis of growing rats
por: Feng, Junpeng, et al.
Publicado: (2021)

Novel Insight into the Role of the Kiss1/GPR54 System in Energy Metabolism in Major Metabolic Organs
por: Li, Xuehan, et al.
Publicado: (2022)

Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4-b][1,4]oxazine derivatives as potent GPR 119 agonists
por: Fang, Yuanying, et al.
Publicado: (2019)

Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy
por: Abbara, Ali, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_fqehgfct20hug40lpf743q9p8c