Cargando…

Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3

Lysyl hydroxylases catalyze hydroxylation of collagen lysines, and sustain essential roles in extracellular matrix (ECM) maturation and remodeling. Malfunctions in these enzymes cause severe connective tissue disorders. Human lysyl hydroxylase 3 (LH3/PLOD3) bears multiple enzymatic activities, as it...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scietti, Luigi, Chiapparino, Antonella, De Giorgi, Francesca, Fumagalli, Marco, Khoriauli, Lela, Nergadze, Solomon, Basu, Shibom, Olieric, Vincent, Cucca, Lucia, Banushi, Blerida, Profumo, Antonella, Giulotto, Elena, Gissen, Paul, Forneris, Federico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082870/ https://www.ncbi.nlm.nih.gov/pubmed/30089812 http://dx.doi.org/10.1038/s41467-018-05631-5

Ejemplares similares

Author Correction: Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
por: Scietti, Luigi, et al.
Publicado: (2018)

A Fe(2+)-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes
por: Scietti, Luigi, et al.
Publicado: (2022)

Identification of Regulatory Molecular “Hot Spots” for LH/PLOD Collagen Glycosyltransferase Activity
por: Mattoteia, Daiana, et al.
Publicado: (2023)

The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability
por: Wang, Chunguang, et al.
Publicado: (2009)

The Activities of Lysyl Hydroxylase 3 (LH3) Regulate the Amount and Oligomerization Status of Adiponectin
por: Ruotsalainen, Heli, et al.
Publicado: (2012)

TERRA Expression Levels Do Not Correlate with Telomere Length and Radiation Sensitivity in Human Cancer Cell Lines
por: Smirnova, Alexandra, et al.
Publicado: (2013)

Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)-induced dissecting abdominal aortic aneurysm
por: Li, Hao, et al.
Publicado: (2021)

Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network
por: Yang, Zihan, et al.
Publicado: (2023)

Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis
por: Banushi, Blerida, et al.
Publicado: (2016)

More on the Lack of Correlation between Terra Expression and Telomere Length
por: Vitelli, Valerio, et al.
Publicado: (2013)

Overlapping Machinery in Lysosome-Related Organelle Trafficking: A Lesson from Rare Multisystem Disorders
por: Banushi, Blerida, et al.
Publicado: (2022)

A Comprehensive Review of the Current Status of the Cellular Neurobiology of Psychedelics
por: Banushi, Blerida, et al.
Publicado: (2023)

Uncoupling of Satellite DNA and Centromeric Function in the Genus Equus
por: Piras, Francesca M., et al.
Publicado: (2010)

Characterisation of the Drosophila procollagen lysyl hydroxylase, dPlod
por: Bunt, Stephanie, et al.
Publicado: (2011)

Early-Life Telomere Dynamics Differ between the Sexes and Predict Growth in the Barn Swallow (Hirundo rustica)
por: Parolini, Marco, et al.
Publicado: (2015)

Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases
por: Kamel, Marwa, et al.
Publicado: (2017)

Erratum to “Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases”
por: Kamel, Marwa, et al.
Publicado: (2018)

Gene amplification in human cells knocked down for RAD54
por: Ruiz-Herrera, Aurora, et al.
Publicado: (2011)

Yolk vitamin E prevents oxidative damage in gull hatchlings
por: Parolini, Marco, et al.
Publicado: (2017)

Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes
por: Terajima, Masahiko, et al.
Publicado: (2022)

Multifunctional Lysyl Oxidases
por: Trackman, Philip C.
Publicado: (2023)

Lysyl Hydroxylase 3 Modifies Lysine Residues to Facilitate Oligomerization of Mannan-Binding Lectin
por: Risteli, Maija, et al.
Publicado: (2014)

Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe(2+)-binding
por: Guo, Hou-Fu, et al.
Publicado: (2018)

Lysyl hydroxylases are transcription targets for GATA3 driving lung cancer cell metastasis
por: Liu, Wei, et al.
Publicado: (2018)

Telomeric Repeat-Containing RNAs (TERRA) Decrease in Squamous Cell Carcinoma of the Head and Neck Is Associated with Worsened Clinical Outcome
por: Vitelli, Valerio, et al.
Publicado: (2018)

Berberine Attenuates Cell Motility via Inhibiting Inflammation-Mediated Lysyl Hydroxylase-2 and Glycolysis
por: Du, Yishan, et al.
Publicado: (2022)

Genome-wide evolutionary and functional analysis of the Equine Repetitive Element 1: an insertion in the myostatin promoter affects gene expression
por: Santagostino, Marco, et al.
Publicado: (2015)

Pitx2 Regulates Procollagen Lysyl Hydroxylase (Plod) Gene Expression: Implications for the Pathology of Rieger Syndrome
por: Hjalt, Tord A., et al.
Publicado: (2001)

Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa
por: Watt, Stephen A., et al.
Publicado: (2015)

Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe(2+)-binding
por: Guo, Hou-Fu, et al.
Publicado: (2018)

Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking
por: Gross, Stephen J., et al.
Publicado: (2021)

Autosomal Recessive Keratoderma-Ichthyosis-Deafness (ARKID) Syndrome Is Caused by VPS33B Mutations Affecting Rab Protein Interaction and Collagen Modification
por: Gruber, Robert, et al.
Publicado: (2017)

An Optical Fiber Chemical Sensor for the Detection of Copper(II) in Drinking Water †
por: Pesavento, Maria, et al.
Publicado: (2019)

Correction to: Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking
por: Gross, Stephen J., et al.
Publicado: (2021)

Breathwork Interventions for Adults with Clinically Diagnosed Anxiety Disorders: A Scoping Review
por: Banushi, Blerida, et al.
Publicado: (2023)

Indium/Gallium Maltolate Effects on Human Breast Carcinoma Cells: In Vitro Investigation on Cytotoxicity and Synergism with Mitoxantrone
por: Merli, Daniele, et al.
Publicado: (2018)

Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression
por: He, Jin-Yong, et al.
Publicado: (2018)

Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas
por: Sato, Kotaro, et al.
Publicado: (2021)

Cerebral small vessel disease caused by PLOD3 mutation: Expanding the phenotypic spectrum of lysyl hydroxylase‐3 deficiency
por: Zhou, Ji, et al.
Publicado: (2022)

Antibody/Ligand-Target Receptor Internalization Assay Protocol Using Fresh Human or Murine Tumor Ex Vivo Samples
por: Joseph, Shannon R., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vatleg1d4hs0vrjf0a6f2bjlar