Two-fold elevation of endogenous GDNF levels in mice improves motor coordination without causing side-effects

Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopaminergic neurons in vitro and in vivo. For this reason, GDNF is currently in clinical trials for the treatment of Parkinson’s disease (PD). However, how endogenous GDNF influences dopamine system function and animal beha...

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Detalles Bibliográficos
Autores principales: Mätlik, Kärt, Võikar, Vootele, Vilenius, Carolina, Kulesskaya, Natalia, Andressoo, Jaan-Olle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082872/
https://www.ncbi.nlm.nih.gov/pubmed/30089897
http://dx.doi.org/10.1038/s41598-018-29988-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082872/
https://www.ncbi.nlm.nih.gov/pubmed/30089897
http://dx.doi.org/10.1038/s41598-018-29988-1

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