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Two-fold elevation of endogenous GDNF levels in mice improves motor coordination without causing side-effects
Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopaminergic neurons in vitro and in vivo. For this reason, GDNF is currently in clinical trials for the treatment of Parkinson’s disease (PD). However, how endogenous GDNF influences dopamine system function and animal beha...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082872/ https://www.ncbi.nlm.nih.gov/pubmed/30089897 http://dx.doi.org/10.1038/s41598-018-29988-1 |