Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer

Epigenetic modifications such as aberrant DNA methylation reshape the gene expression repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) mouse model (Alb-R26(Met)) to explore the impact of DNA methylation on transcriptional switches associated with tumorigenesis...

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Detalles Bibliográficos
Autores principales: Arechederra, Maria, Daian, Fabrice, Yim, Annie, Bazai, Sehrish K., Richelme, Sylvie, Dono, Rosanna, Saurin, Andrew J., Habermann, Bianca H., Maina, Flavio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082886/
https://www.ncbi.nlm.nih.gov/pubmed/30089774
http://dx.doi.org/10.1038/s41467-018-05550-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082886/
https://www.ncbi.nlm.nih.gov/pubmed/30089774
http://dx.doi.org/10.1038/s41467-018-05550-5

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