Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality

Mitochondria contain many copies of a circular DNA molecule (mtDNA), which has been observed as a mixture of normal and mutated states known as heteroplasmy. Elevated heteroplasmy at a single mtDNA site, m.3243A > G, leads to neurologic, sensory, movement, metabolic, and cardiopulmonary impairmen...

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Detalles Bibliográficos
Autores principales: Tranah, Gregory J., Katzman, Shana M., Lauterjung, Kevin, Yaffe, Kristine, Manini, Todd M., Kritchevsky, Stephen, Newman, Anne B., Harris, Tamara B., Cummings, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082898/
https://www.ncbi.nlm.nih.gov/pubmed/30089816
http://dx.doi.org/10.1038/s41598-018-30255-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082898/
https://www.ncbi.nlm.nih.gov/pubmed/30089816
http://dx.doi.org/10.1038/s41598-018-30255-6

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