Fate of the UPR marker protein Kar2/Bip and autophagic processes in fed-batch cultures of secretory insulin precursor producing Pichia pastoris

BACKGROUND: Secretory recombinant protein production with Pichia (syn. Komagataella) pastoris is commonly associated with the induction of an unfolded protein response (UPR) usually apparent through increased intracellular levels of endoplasmic reticulum (ER) resident chaperones such as Kar2/Bip. Du...

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Detalles Bibliográficos
Autores principales: Roth, Gustavo, Vanz, Ana Letícia, Lünsdorf, Heinrich, Nimtz, Manfred, Rinas, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083527/
https://www.ncbi.nlm.nih.gov/pubmed/30092809
http://dx.doi.org/10.1186/s12934-018-0970-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083527/
https://www.ncbi.nlm.nih.gov/pubmed/30092809
http://dx.doi.org/10.1186/s12934-018-0970-3

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