Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents

Metastatic cancer is considered a fatal progression of cancer worldwide. It has been shown that a key player in this scenario is the CXC chemokine receptor 2 (CXCR2). To identify novel CXCR2 antagonists, a pharmacophore model was built with the HipHop program by screening a database containing compo...

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Detalles Bibliográficos
Autores principales: Che, Jinxin, Wang, Zhilong, Sheng, Haichao, Huang, Feng, Dong, Xiaowu, Hu, Youhong, Xie, Xin, Hu, Yongzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083693/
https://www.ncbi.nlm.nih.gov/pubmed/30109074
http://dx.doi.org/10.1098/rsos.180176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083693/
https://www.ncbi.nlm.nih.gov/pubmed/30109074
http://dx.doi.org/10.1098/rsos.180176

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