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Site-specific structural order in Alzheimer's Aβ42 fibrils

Deposition of amyloid fibrils is a pathological hallmark of Alzheimer's disease. Aβ42 is the major protein whose aggregation leads to the formation of these fibrils. Understanding the detailed structure of Aβ42 fibrils is of particular importance for delineating the mechanism of Aβ42 aggregatio...

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Detalles Bibliográficos
Autores principales: Wang, Hongsu, Lee, Yoon Kyung, Xue, Christine, Guo, Zhefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083707/
https://www.ncbi.nlm.nih.gov/pubmed/30109072
http://dx.doi.org/10.1098/rsos.180166