Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats

The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar–Hannover rats were administered imipramine acutely or chronically in the morning or in t...

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Detalles Bibliográficos
Autores principales: Kawai, Hiroshi, Kodaira, Natsumi, Tanaka, Chika, Ishibashi, Takuya, Kudo, Naomi, Kawashima, Yoichi, Mitsumoto, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083812/
https://www.ncbi.nlm.nih.gov/pubmed/30210565
http://dx.doi.org/10.5334/jcr.156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083812/
https://www.ncbi.nlm.nih.gov/pubmed/30210565
http://dx.doi.org/10.5334/jcr.156

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