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Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats
The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar–Hannover rats were administered imipramine acutely or chronically in the morning or in t...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Ubiquity Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083812/ https://www.ncbi.nlm.nih.gov/pubmed/30210565 http://dx.doi.org/10.5334/jcr.156 |