A Mechanistic Computational Model Reveals That Plasticity of CD4(+) T Cell Differentiation Is a Function of Cytokine Composition and Dosage

CD4(+) T cells provide cell-mediated immunity in response to various antigens. During an immune response, naïve CD4(+) T cells differentiate into specialized effector T helper (Th1, Th2, and Th17) cells and induced regulatory (iTreg) cells based on a cytokine milieu. In recent studies, complex pheno...

Descripción completa

Detalles Bibliográficos
Autores principales: Puniya, Bhanwar Lal, Todd, Robert G., Mohammed, Akram, Brown, Deborah M., Barberis, Matteo, Helikar, Tomáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083813/
https://www.ncbi.nlm.nih.gov/pubmed/30116195
http://dx.doi.org/10.3389/fphys.2018.00878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083813/
https://www.ncbi.nlm.nih.gov/pubmed/30116195
http://dx.doi.org/10.3389/fphys.2018.00878

Ejemplares similares