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A Mechanistic Computational Model Reveals That Plasticity of CD4(+) T Cell Differentiation Is a Function of Cytokine Composition and Dosage
CD4(+) T cells provide cell-mediated immunity in response to various antigens. During an immune response, naïve CD4(+) T cells differentiate into specialized effector T helper (Th1, Th2, and Th17) cells and induced regulatory (iTreg) cells based on a cytokine milieu. In recent studies, complex pheno...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083813/ https://www.ncbi.nlm.nih.gov/pubmed/30116195 http://dx.doi.org/10.3389/fphys.2018.00878 |