Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

Horizontal pleiotropy occurs when the variant has an effect on disease outside of its effect on the exposure in Mendelian randomization (MR). Violation of the ‘no horizontal pleiotropy’ assumption can cause severe bias in MR. We developed the Mendelian Randomization Pleiotropy RESidual Sum and Outli...

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Detalles Bibliográficos
Autores principales: Verbanck, Marie, Chen, Chia-Yen, Neale, Benjamin, Do, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083837/
https://www.ncbi.nlm.nih.gov/pubmed/29686387
http://dx.doi.org/10.1038/s41588-018-0099-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083837/
https://www.ncbi.nlm.nih.gov/pubmed/29686387
http://dx.doi.org/10.1038/s41588-018-0099-7

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