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Understanding sequencing data as compositions: an outlook and review

MOTIVATION: Although seldom acknowledged explicitly, count data generated by sequencing platforms exist as compositions for which the abundance of each component (e.g. gene or transcript) is only coherently interpretable relative to other components within that sample. This property arises from the...

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Detalles Bibliográficos
Autores principales: Quinn, Thomas P, Erb, Ionas, Richardson, Mark F, Crowley, Tamsyn M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084572/
https://www.ncbi.nlm.nih.gov/pubmed/29608657
http://dx.doi.org/10.1093/bioinformatics/bty175