A comparison of anticonvulsant efficacy and action mechanism of Mannitol vs Phenytoin in adult rat neocortical slices

We show that, in adult rat neocortical slices, an anticonvulsant effect comparable to that of Phenytoin can be obtained through a Mannitol-induced increase in extracellular osmolarity of only 30 mOsm/L. The anticonvulsant action of extracellular hyperosmolarity has been known for decades but has not...

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Detalles Bibliográficos
Autor principal: Serafini, Ruggero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084822/
https://www.ncbi.nlm.nih.gov/pubmed/30135942
http://dx.doi.org/10.1016/j.ibror.2017.09.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084822/
https://www.ncbi.nlm.nih.gov/pubmed/30135942
http://dx.doi.org/10.1016/j.ibror.2017.09.002

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