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A comparison of anticonvulsant efficacy and action mechanism of Mannitol vs Phenytoin in adult rat neocortical slices
We show that, in adult rat neocortical slices, an anticonvulsant effect comparable to that of Phenytoin can be obtained through a Mannitol-induced increase in extracellular osmolarity of only 30 mOsm/L. The anticonvulsant action of extracellular hyperosmolarity has been known for decades but has not...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084822/ https://www.ncbi.nlm.nih.gov/pubmed/30135942 http://dx.doi.org/10.1016/j.ibror.2017.09.002 |