CuATSM efficacy is independently replicated in a SOD1 mouse model of ALS while unmetallated ATSM therapy fails to reveal benefits

A copper chelator known as diacetylbis(N(4)-methylthiosemicarbazonato) copper II (CuATSM), has been reported to be efficacious in multiple transgenic SOD1 models of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder affecting motor neurons. Here we report that we also observed C...

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Detalles Bibliográficos
Autores principales: Vieira, Fernando G., Hatzipetros, Theo, Thompson, Kenneth, Moreno, Andy J., Kidd, Joshua D., Tassinari, Valerie R., Levine, Beth, Perrin, Steven, Gill, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084867/
https://www.ncbi.nlm.nih.gov/pubmed/30135932
http://dx.doi.org/10.1016/j.ibror.2017.03.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084867/
https://www.ncbi.nlm.nih.gov/pubmed/30135932
http://dx.doi.org/10.1016/j.ibror.2017.03.001

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