Cargando…

Functional aspects of meningeal lymphatics in aging and Alzheimer’s disease

Aging is a major risk factor for many neurological pathologies and the mechanisms underlying brain aging remain elusive. Unlike other tissues, the central nervous system (CNS) parenchyma is devoid of lymphatic vasculature and removal of waste products is performed mainly through a paravascular route...

Descripción completa

Detalles Bibliográficos
Autores principales:	Da Mesquita, Sandro, Louveau, Antoine, Vaccari, Andrea, Smirnov, Igor, Cornelison, R. Chase, Kingsmore, Kathryn M., Contarino, Christian, Onengut-Gumuscu, Suna, Farber, Emily, Raper, Daniel, Viar, Kenneth E., Powell, Romie D., Baker, Wendy, Dabhi, Nisha, Bai, Robin, Cao, Rui, Hu, Song, Rich, Stephen S., Munson, Jennifer M., Lopes, M. Beatriz, Overall, Christopher C., Acton, Scott T., Kipnis, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085146/ https://www.ncbi.nlm.nih.gov/pubmed/30046111 http://dx.doi.org/10.1038/s41586-018-0368-8

Ejemplares similares

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature
por: Louveau, Antoine, et al.
Publicado: (2018)

Microbiota alteration is associated with the development of stress-induced despair behavior
por: Marin, Ioana A., et al.
Publicado: (2017)

Convective forces increase CXCR4-dependent glioblastoma cell invasion in GL261 murine model
por: Cornelison, R. Chase, et al.
Publicado: (2018)

Meningeal Lymphatics: An Immune Gateway for the Central Nervous System
por: Tavares, Gabriel A., et al.
Publicado: (2021)

Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes
por: Brænne, Ingrid, et al.
Publicado: (2021)

Precision Medicine in Type 1 Diabetes
por: Michalek, Dominika A., et al.
Publicado: (2023)

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI
por: Absinta, Martina, et al.
Publicado: (2017)

Perspective on Translating Biomaterials Into Glioma Therapy: Lessons From in vitro Models
por: Cornelison, R. Chase, et al.
Publicado: (2018)

Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains
por: Wang, Qian, et al.
Publicado: (2015)

MRI analysis to map interstitial flow in the brain tumor microenvironment
por: Kingsmore, Kathryn M., et al.
Publicado: (2018)

Charting the meningeal lymphatic network
por: Da Mesquita, Sandro
Publicado: (2022)

Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia
por: Cronk, James C., et al.
Publicado: (2018)

Structural and functional features of central nervous system lymphatics
por: Louveau, Antoine, et al.
Publicado: (2015)

Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology
por: Da Mesquita, Sandro, et al.
Publicado: (2021)

Recurrence of a large intracranial fusiform aneurysm treated with overlapping Pipeline embolization devices: illustrative case
por: Kumar, Jeyan Sathia, et al.
Publicado: (2023)

The Diagnosis of Lymphatic Obstruction of Filarial Origin
por: Acton, Hugh W., et al.
Publicado: (1931)

Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens
por: Jia, Xiaoming, et al.
Publicado: (2013)

Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease
por: Rego, Shanon, et al.
Publicado: (2023)

Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes
por: Newman, Jeremy R.B., et al.
Publicado: (2017)

Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury
por: Gadani, Sachin P., et al.
Publicado: (2017)

Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes
por: Ge, Yan, et al.
Publicado: (2016)

TXNIP DNA methylation is associated with glycemic control over 28 years in type 1 diabetes: findings from the Pittsburgh Epidemiology of Diabetes Complications (EDC) study
por: Miller, Rachel G, et al.
Publicado: (2023)

Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes
por: Newman, Jeremy R. B., et al.
Publicado: (2023)

CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges
por: das Neves, Sofia Pereira, et al.
Publicado: (2021)

Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage
por: Rustenhoven, Justin, et al.
Publicado: (2023)

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
por: Bolte, Ashley C., et al.
Publicado: (2020)

A Genome-Wide Assessment of the Role of Untagged Copy Number Variants in Type 1 Diabetes
por: Zanda, Manuela, et al.
Publicado: (2014)

DNA methylation and 28-year cardiovascular disease risk in type 1 diabetes: the Epidemiology of Diabetes Complications (EDC) cohort study
por: Miller, Rachel G., et al.
Publicado: (2023)

Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation
por: Wang, T. Tiffany, et al.
Publicado: (2020)

Docetaxel facilitates lymphatic-tumor crosstalk to promote lymphangiogenesis and cancer progression
por: Harris, Alexandra R., et al.
Publicado: (2018)

The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway
por: Tran, Paul MH., et al.
Publicado: (2021)

Evidence for two independent associations with type 1 diabetes at the 12q13 locus
por: Keene, Keith L., et al.
Publicado: (2011)

Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
por: Al-Barghouthi, Basel M., et al.
Publicado: (2021)

A Method for Gene-Based Pathway Analysis Using Genomewide Association Study Summary Statistics Reveals Nine New Type 1 Diabetes Associations
por: Evangelou, Marina, et al.
Publicado: (2014)

Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm’s Canal Reporter Rat
por: Jung, Eunson, et al.
Publicado: (2017)

Clickable Biomaterials for Modulating Neuroinflammation
por: Cornelison, Chase, et al.
Publicado: (2022)

Leveraging type 1 diabetes human genetic and genomic data in the T1D Knowledge Portal
por: Kudtarkar, Parul, et al.
Publicado: (2023)

Leveraging type 1 diabetes human genetic and genomic data in the T1D knowledge portal
por: Kudtarkar, Parul, et al.
Publicado: (2023)

Fine Mapping and Functional Studies of Risk Variants for Type 1 Diabetes at Chromosome 16p13.13
por: Tomlinson, M. Joseph, et al.
Publicado: (2014)

Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels
por: Liu, Xuanhui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r1jm6ks15r5d4p2l45oadh6pqe