Isobenzofuranone derivative JVPH3, an inhibitor of L. donovani topoisomerase II, disrupts mitochondrial architecture in trypanosomatid parasites

Kinetoplast DNA (kDNA) bearing unusual mitochondrion of trypanosomatid parasites offers a new paradigm in chemotherapy modality. Topoisomerase II of Leishmania donovani (LdTopII), a key enzyme associated with kDNA replication, is emerging as a potential drug target. However, mode of action of LdTopI...

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Detalles Bibliográficos
Autores principales: Chowdhury, Somenath Roy, Godinho, Joseane Lima Prado, Vinayagam, Jayaraman, Zuma, Aline Araujo, Silva, Sara Teixeira De Macedo, Jaisankar, Parasuraman, Rodrigues, Juliany Cola Fernandes, De Souza, Wanderley, Majumder, Hemanta K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085290/
https://www.ncbi.nlm.nih.gov/pubmed/30093616
http://dx.doi.org/10.1038/s41598-018-30405-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085290/
https://www.ncbi.nlm.nih.gov/pubmed/30093616
http://dx.doi.org/10.1038/s41598-018-30405-w

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